The daily dose of amantadine for treatment or prevention of influenza A can be reduced in patients with renal failure proportionate to the patient's renal function.
daily amantadine dose (in milligrams) =
= 200 * (patient's creatinine clearance) / 120
where:
• 200 represents the usual daily amantadine dose in milligrams;
• The creatinine clearance is expressed as mL per minute;
• 120 represents the normal creatinine clearance in mL per minute.
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