van Dijk et al reported equations for age-stratified dosing of propofol for pediatric sedation or analgesia. One set of equations relates to calculating the maintenance dose. The authors are from UMC Utrecht.
Patient selection: pediatric
Parameters:
(1) sex
(2) ASA status
(3) opiates
(4) procedure group
(5) age in years
Procedure groups:
(1) endoscopic imaging
(2) punctures (bone marrow biopsy, lumbar puncture, etc)
(3) electrophysiology study and ablation
(4) intra-articular injection
(5) miscellaneous
Crude Propofol Maintenance Dose
crude maintenance dose in mg per kg per hour =
= 18.22 - (0.403 * (age))
Adjusted Propofol Maintenance Dose
Parameter
Finding
Points
sex
female
0
male
0.28
ASA status
ASA 1 or 2
ASA 3 or 4
-0.75
opiates
no
yes
0.17
procedure
group 1
-1.23
group 2
0.24
group 3
-3.99
group 4
1.71
group 5
-1.15
score =
= SUM(points for all of the parameters) + 17.74
adjusted propofol dose in mg/kg per hour =
= (score) - (0.36 * (age))
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Specialty: Anesthesiology, Surgery, general
