Equation for Single Bolus
area under the curve in nanogram • hour per mL =
= (17.39 * (concentration in ng/mL at 2 hours after bolus)) + (163 * (concentration in ng/mL at 48 hours after bolus)) – (111.0 * ((dose in mg per square meter) / (50 mg per square meter)))
where:
• Dividing by 50 mg per square meter is used to normalize the dose.
Equation for Daily Bolus for 3 Days
area under the curve in nanogram • hour per mL =
= (44.79 * (concentration in ng/mL at 2 hours after bolus)) + (175.65 * (concentration in ng/mL at 48 hours after bolus)) + (47.25 * ((dose in mg per square meter per day) / (25 mg per square meter per day)))
where:
• The 48 hour sample is drawn immediately prior to administering the third dose.
• Dividing by 25 mg per square meter per day is used to normalize the dose.
Performance:
• The equation for the single bolus had a correlation coefficient of 0.89 for predicted vs actual AUC. The mean predictive error for the single bolus equation was about 4.5%.
• The 3-day bolus equation was not validated in patients.
• The models may not function as well in patients with altered doxorubicin clearance as it does in patients with relatively normal clearance.
