A male may develop hypergonadotropic hypogonadism due to a number of causes.
Features:
(1) hypogonadism
(2) elevated gonadotropins (FSH, LH)
Mechanisms:
(A) interference with androgen synthesis
(B) blocking the androgen receptor
(C) damage to seminiferous tubules)
Drugs that can cause hypergonadotropic hypogonadism include:
(1) alcohol
(2) aminogluthimide (A)
(3) etomidate (A)
(4) ketoconazole (A)
(5) steroids (A)
(6) spironolactone (B)
(7) cyproterone acetate (B)
(8) flutamide (B)
(9) alkylating agents (C)
(10) cyclophosphamide (C)
(11) busulphan (C)
(12) chlorambucil (C)
