Patient selection: COVID-19
Parameters:
(1) serum interleukin-6 on day 0 (admission) in pg/mL
(2) serum interluekin-10 on day 0 in pg/mL
(3) serum interleukin-6 on day 4
(4) serum interleukin-10 on day 4
ratio of interleukin-6 to interleukin-10 on day 0 =
= (interleukin-6 on day 0) / (interleukin-10 on day 0)
ratio of interleukin-6 to interleukin-10 on day 4 =
= (interleukin-6 on day 4) / (interleukin-10 on day 4)
difference in ratio from day 0 to day 4 =
= (ratio on day 4) - (ratio on day 0)
Transformation of score:
(1) multiply by 2
(2) round to an integer
(3) MAX set to 2
(4) MIN set to -2
This results in a possible value of -2, -1, 0, 1 or 2.
Interpretation:
• The higher the score the worse the prognosis.
