Effects of Drugs on Bile Flow and Composition

Drugs and chemicals associated with increased bile flow (choleretics):

(1) bile acids (ursodeoxycholic acid, ursocholic acid, dehydrocholate)

(2) phenobarbital

(3) theophylline

(4) glucagon

(5) insulin

(6) aspirin

(7) secretin

Drugs associated with decreased bile flow:

(1) ethacrynic acid

(2) amiloride

(3) oubain

(4) estrogens

(5) chlorpromazine

(6) somatostatin

(7) vinblastine

(8) rifampicin

(9) rifamycin

Drugs associated with altered biliary bile acid secretion:

(1) chenodeoxycholic acid (CDCA)

(2) ursodeoxycholic acid (UDCA)

(3) cholestyramine

(4) colestipol

(5) ethinyloestradiol

(6) clofibrate

(7) colchicine

(8) vinblastine

Drugs that increase biliary cholesterol saturation:

(1) nicotinic acid

(2) d-thyroxine

(3) clofibrate

Drugs that reduce biliary cholesterol concentration:

(1) CDCA

(2) UDCA