A patient who has had a hematopoietic stem cell transplant (HSCT) for a childhood cancer may experience exercise intolerance.
Patient selection: cancer survivor with history of a hematopoietic stem cell transplant (HSCT)
Factors associated with poor exercise tolerance:
(1) cardiac toxicity from chemotherapy
(2) abnormal respiratory function
(3) skeletal muscle dysfunction
(4) systemic inflammation (Graft vs Host Disease, cytokine effects, other)
(5) disuse atrophy
(6) depression
Manifestations:
(1) low amounts of daily physical activity
(2) poor aerobic exercise capacity
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Specialty: Surgery, orthopedic
