The Familial Atypical Multiple Mole Melanoma (FAMMM)-Pancreatic Carcinoma Syndrome is an uncommon disorder associated with mutations of a tumor suppressor gene.
Gene: CDKN2A (cyclin dependent kinase inhibitor 2A)
Location: 9p21
Inheritance: autosomal dominant
Cliniical features:
(1) multiple atypical nevi and melanomas
(2) increased risk for pancreatic carcinoma
(3) variable risk for other malignancies (sarcoma, esophageal carcinoma, breast carcinoma, etc)
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Specialty: Hematology Oncology, Genetics, Surgery, general
