Nazha et al used a simple mutated gene count to predict the prognosis for a patient with myelodysplasia. This can be used in combination with blast count and IPSS-R. The authors are from multiple institutions from the United States and Germany.
Patient selection: myelodysplasia
Genes analyzed:
(1) ASXL1
(2) EZH2
(3) RUNX1
(4) SRSF2
(5) RAD21
(6) STAG2
(7) SF3B1
(8) TP53
(9) KRAS
(10) NRAS
Gene
Points
wild type
0
mutated
1
total score =
= SUM(points for all 10 genes)
Interpretation:
• minimum score: 0
• maximum score: 10
• The risk for the patient increased with the number of genes mutated.
Score
Median Overall Survival
Median Leukemia-Free Survival
0
70 months
not reached
1 or 2
59 months
not reached
3 or 4
36 months
220 months
5 to 10
21 months
32 months
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