Passmore et al developed a prognostic score for patients with pediatric myelodysplasia. The FPC (hemoglobin F, Platelet count, Cytogenetic) score correlates with survival. The authors are from several hospitals in London.
Parameters for prognostic score, based on findings at the time of diagnosis:
(1) F: hemoglobin F levels
(2) P: platelet count
(3) C: cytogenetic abnormalities
Parameter
Findings
Points
hemoglobin F levels
<= 10%
0
> 10%
1
platelet count
> 40,000 per µL
0
<= 40,000 per µL
1
cytogenetics
no abnormalities
0
1 clonal structural or numerical abnormality
0
>= 2 clonal structural or numerical abnormalities (complex karyotypic changes)
1
where:
• The presence of 2 or more clonal structural or numerical abnormalities is termed "complex karyotypic changes".
FPC prognostic score =
= SUM(points for all 3 factors)
Interpretation:
• minimum score: 0
• maximum score: 3
Score
Survival
0
62% at 10 years
1
20% at 10 years
2 or 3
0% at 4 years
after Figure 3 page 1747
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