Long et al developed the Framingham Steatosis Index (FSI) for identifying patients with hepatic steatosis. The authors are from Boston University, University of Alabama, Massachusetts General Hospital, Brigham and Women's Hospital and the National Heart, Lung, and Blood Institute.
Patient selection: adults from Framingham, Massachusetts
Method: multivariate stepwise regression
Parameters:
(1) age in year
(2) sex
(3) body mass index in kilograms per square meter
(4) serum trigylceride concentration in mg/dL
(5) hypertension
(6) diabetes
(7) ALT to AST ratio
ALT to AST ratio =
= (serum ALT in IU/L) / (serum AST in IU/L)
Parameter
Finding
Points
age in years
0.011 * (years)
sex
male
0
female
-0.146
BMI
0.173 * (BMI)
trigylcerides
0.007 * (triglycerides)
hypertension
no
0
yes
0.593
diabetes
no
0
yes
0.789
ALT to AST ratio
< 1.33
0
>= 1.33
1.1
FSI =
= SUM(points for all 7 parameters) - 7.981
Presumably
probability of steatosis =
= 1 / (1 + EXP((-1) * FSI))
Performance:
• The area under the ROC curve was 0.85.
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