The gene expression pattern shown by a breast cancer may correlate with the patient’s prognosis. Sorlie et al recognized 6 different patterns.
Method: hierarchical clustering of 456 cDNA clones
Pattern |
Features |
luminal A |
strong luminal cell gene expression including strong ER |
luminal B |
low to moderate luminal cell gene expression including ER |
luminal C |
low to moderate luminal cell gene expression including ER, high expression of novel set of genes seen also in basal cell and ERBB2 subtypes |
normal breast-like |
expresses genes seen in adipose and nonepithelial tissue, low to absent ER and luminal genes, strong basal epithelial genes |
ERRB2+ (HER2 +) |
HER2 positive, low to absent ER and luminal genes |
basal cell-like |
basal cell genes, low to absent ER and luminal genes, CK5 and CK17, laminin, FABP7 |
Pattern |
5-Year Overall Survival |
luminal A |
90% |
luminal B |
49% |
luminal C |
42% |
normal breast |
52% |
ERRB2+ (HER2 +) |
30% |
basal cell |
0% |
from Sorlie et al 2001, Figure 3
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
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