Grades of Ojiri et al for CT Scan Documented Response to Therapy of an Oropharyngeal Squamous Cell Carcinoma

Description

Ojiri et al graded the response to therapy of primary squamous cell carcinoma of the oropharynx based on changes seen on CT (computed tomography) images. This can help identify patients who may require more aggressive management. The authors are from the University of Florida at Gainesville, Florida.

Parameters:

(1) pretreatment dimensions of tumor

(2) dimensions of tumor after therapy

(3) appearance after therapy

post-treatment diameter as percent of pretreatment diameter =

= (post-treatment diameter in cm) / (pre-treatment diameter in cm) * 100%

Dimensions of Tumor After Therapy	Appearance After Therapy	Grade of Response
diameter after therapy >= 50% pretreatment diameter (reduction in maximum dimension < 50%)	NA	2b
diameter after treatment > 10 mm AND diameter after therapy < 50% pretreatment diameter	NA	2a
diameter after treatment <= 10 mm	NA	1
NA	anatomic asymmetry	1
NA	no detectable focal abnormality	0

where:

• The grading scheme is ambiguous for a tumor that is <= 10 mm in diameter after treatment but which is >= 50% of pretreatment size. This could be an issue for tumors that have a pretreatment diameter of up to 1.9 cm (19 mm). In the implementation I will be classify this as Grade 1, based on the assumption that all Grade 2 lesions should be > 10 mm after treatment.

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Grades of Ojiri et al for CT Scan Documented Response to Therapy of an Oropharyngeal Squamous Cell Carcinoma

Description

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