The International Study Group of Liver Surgery (ISGLS) reported a grading system for bile leakage after hepatobiliary or pancreatic surgery.
Criteria for bile leakage - one or both of the following:
(1) drain or intra-abdominal drain fluid with an increased bilirubin concentration on or after postoperative day 3 (with fluid bilirubin concentration >= 3 times concurrent serum concentation)
(2) need for an intervention because of biliary collection or bile peritonitis