The Japan Society for Cancer Therapy developed histopathologic criteria for evaluating the effect of chemotherapy on a solid tumor.
Parameters:
(1) tumor cell degeneration
(2) tumor cell necrosis
(3) tumor cell cytolysis
(4) tissue response
Degeneration, Necrosis and or Cytolysis
Tissue Reaction
Grade of Chemotherapy Effect
none to few cancer cells
NA
0 (none)
less than one third of cancer cells
1A (very mild)
one third to two thirds of cancer cells
1B (mild)
over two thirds of cancer cells but not all
2 (moderate)
all cancer cells
granulomatous tissue or fibrosis
3 (marked)
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Specialty: Hematology Oncology, Surgery, general
