Grading Mastocytosis in the Skin (MIS) Symptoms

Description

Valent et al described a grading scale for symptoms associated with mastocytosis in the skin (MIS). This can help to monitor a patient over time and to assess the response to therapy. The authors are from multiple universities in North America and Europe.

Skin-related symptoms:

(1) pruritis

(2) flushing

(3) blistering or bullae

Intensity of the Symptom	Grade
none (absent)	0
mild, infrequent, requires no therapy	1
mild to moderate, frequent, controlled with therapy	2
severe, frequent, difficult to control	3
severe, requiring hospitalization	4

A Grade 4 symptom is referred to as severe adverse event (SAE).

Frequency of the SAE	Designation
less than once a year	A
at least once a year but less than once a month	B
once a month or more often	C

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Description

Specialty

ICD-10