Grading Myocardial Iron Overload (MIO) in Transfusion-Dependent Thalassemia

Myocardial iron overload (MIO) in transfusion-dependent thalassemia can be graded based on the amount of iron in the myocardium.

Patient selection: transfusion-dependent thalassemia

Analysis: amount of iron in mg in a mass of myocardium weighed in grams, which may be determined from:

(1) a myocardial biopsy

(2) T2* weighted MRI

iron content in myocardium =

= (mg of iron) / (weight of myocardium in grams)

Iron Content in mg per gram myocardium	Grade
< 1.16 mg per g	normal
1.16 to 1.64 mg per g	mild iron overload
1.65 to 2.70 mg per g	moderate iron overload
>= 2.71 mg per g	severe iron overload

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