The clinical and laboratory findings in a patient with acute leukemia can be graded using the rating criteria listed by Kurtzberg et al. This can be used to monitor the changes following chemotherapy.
NOTE: The grading scheme can be applied to patients with either ALL or AML.
Parameters (total 10):
(1) clinical symptoms and performance (2)
(2) physical findings (3)
(3) hemogram/CBC (4)
(4) percent blasts in the bone marrow (1)
|
Parameters |
Findings |
Rating |
|---|---|---|
|
symptoms |
asymptomatic |
1 |
|
|
moderately symptomatic |
2 |
|
|
markedly symptomatic |
3 |
|
performance |
ECOG 0 and 1 (normal activity) |
1 |
|
|
ECOG 2 (< 50% of time in bed) |
2 |
|
|
ECOG 3 and 4 (>= 50% of time in bed) |
3 |
|
liver on physical examination |
normal for age |
1 |
|
|
down to umbilicus |
2 |
|
|
below umbilicus |
3 |
|
spleen on physical examination |
normal for age |
1 |
|
|
abnormal |
2 |
|
|
grossly visible |
3 |
|
other findings on physical examination |
normal for age |
1 |
|
|
definite |
2 |
|
|
marked |
3 |
|
hemoglobin |
age < 2 years and >= 10 g/dL |
1 |
|
|
age < 2 years and 7 - 9.9 g/dL |
2 |
|
|
age >= 2 years and >= 11 g/dL |
1 |
|
|
age >= 2 years and 7 - 10.9 g/dL |
2 |
|
|
< 7 g/dL |
3 |
|
absolute neutrophil count |
> 1,500 per µL |
1 |
|
|
500 to 1,500 per µL |
2 |
|
|
< 500 per µL |
3 |
|
percent blasts in peripheral blood differential |
0 |
1 |
|
|
0.1% to 5% |
2 |
|
|
> 5% |
3 |
|
platelet count |
> 100,000 per µL |
1 |
|
|
25,000 to 100,000 per µL |
2 |
|
|
< 25,000 per µL |
3 |
|
percent blasts in the bone marrow |
<= 5% |
1 |
|
|
6 - 25% |
2 |
|
|
> 25% |
3 |
where:
• I rated mild symptoms (not listed) as 2.
Specialty: Hematology Oncology
ICD-10: ,
