Guidance Graph of Simpson and Souter for the Infusion Rate of Atracurium

Description

Simpson and Souter developed a "guidance" graph for determining the infusion rate of atracurium following an intravenous bolus dose. This can help determine the infusion rate more accurately. The authors are from Falkirk and District Royal Infirmary in Scotland.

The graph can be used to predict the infusion rate of atracurium based on the time to return to threshold after a 35 mg bolus IV.

Minutes	Infusion Rate in mg per hour
10	37.4
15	30.8
20	24.7
25	20.5
30	17.1
35	14.5
40	12.7
45	11.3
50	10.1
55	9.3
60	8.5
65	8.2

When analyzed in JMP this can be approximated by the following equation:

infusion rate in mg per hour =

= (-0.000197 * ((time to return)^3)) + (0.0344775 * ((time to return)^2)) - (2.1385 * (time to return)) + 55.5522

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Description

Specialty

ICD-10