Hsu et al reported a simple score for determining hepatic fibrosis in a patient with chronic hepatitis B using laboratory test results. The authors are from Chang Gung Memorial Hospital and Chang Gung University in Taiwan.
HB-F is an acronym for hepatitis B fibrosis.
Patient selection: chronic hepatitis B
Parameters:
(1) age in years
(2) serum AST in IU/L
(3) serum ALT in IU/L
(4) platelet count in 10^3/µL
(5) PT prolongation in seconds (presumably patient PT minus normal PT)
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Parameter
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Points
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age in years
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0.018 * (age)
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serum AST and ALT
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1.085 * (AST) / (ALT)
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platelet count
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-0.009 * (platelet count)
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PT prolongation
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0.449 * (PT prolongation)
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total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: -1.2
• maximum score: 2.0
• There is significant overlap in groups at lower HB-F scores.
• The higher the score the greater the likelihood of significant fibrosis or cirrhosis.
The boxed area for cirrhosis (fibrosis stage 5+) was 0.06 to 1.22
The boxed area for non-cirrhosis (fibrosis stage 0 to 4) was -0.72 to 0.20.
The boxed area for significant fibrosis (fibrosis stage 4+) was -0.42 to 0.71.
The boxed area for non-significant fibrosis (fibrosis stage 0 to 3) was -0.86 to 0.11
Performance:
• The area under the ROC curve for fibrosis is 0.81 in the training and 0.80 in the validation cohorts.
• The area under the ROC curve for cirrhosis is 0.80 in the training and 0.76 in the validation cohorts.
