Histologic Grades of Kwon et al for Xanthogranulomatous Cholecystitis

Description

Xanthgranulomatous cholecystitis (XGC) is associated with xanthogranulomas in the wall of the gallbladder. Kwon et al identified different histologic grades of xanthogranulomatous cholecystitis. The authors are from the Kansai Medical University in Osaka, Japan.

Histologic components:

(1) foamy histiocytes and xanthoma cells

(2) foreign body type giant cells

(3) acute inflammatory cells (early)

(4) fibrosis (later stages)

Parameters:

(1) degree of infiltration by foamy histiocytes and foreign body type giant cells

(2) degree of fibrosis

Parameters	Findings	Grade
foamy histiocyte and foreign body type giant cell infiltration	none	0
	mild	1
	moderate	1
	severe	2
fibrosis	none	0
	mild	0
	moderate	0
	severe	3

histologic grade =

= MAX(grade for cellular infiltrate, grade for fibrosis)

The presence of dense adhesions (which may be associated with Grade 3 fibrosis of the gallbladder wall) may require an open cholecystectomy.

To read more or access our algorithms and calculators, please log in or register.

Description

Specialty

ICD-10