Histologic Grading of Radiation Effect

Gallet et al reported histopathologic changes associated with acute radiation effect. The authors are from Vandoeuvre-les-Nancy in France.

Patient selection: status post radiation exposure

Parameters:

(1) inflammation

(2) fibrosis

(3) vascular

(4) cellular alteration

Parameter	Histologic Change	Grade
inflammation	no inflammatory infiltrate, none to rare mast cells	0
	some inflammatory cells	1
	frequent inflammatory infiltrates	2
	diffuse inflammation	3
fibrosis	none	0
	minor fibrosis with intact structures	1
	moderate fibrosis with some structural changes	2
	major and diffuse fibrosis	3
vascular	normal number and seize of vessels	0
	decrease in number and/or mild vascular damage	1
	marked reduction in blood vessels and/or moderate vascular damage	2
	avascular or severe damage or thrombosis	3
cellular alterations	normal	0
	some dystrophic nuclei	1
	frequent dystrophic nuclei or scattered cellular necrosis	2
	widespread dystrophic nuclei and/or necrosis amd/or hypocellularity	3

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