Uterine endometrioid adenocarcinoma is graded based on both the architectural and nuclear features seen on histology.
|
Feature |
Finding |
Grade |
|
architecture |
<= 5% of tumor composed of solid masses |
1 |
|
|
6 - 50% of tumor is composed of solid masses |
2 |
|
|
> 50% of tumor is composed of solid masses |
3 |
|
nuclear features |
nuclei oval chromatin evenly dispersed |
1 |
|
|
intermediate between grades 1 and 2 |
2 |
|
|
nuclei markedly enlarged nuclei pleomorphic chromatin irregular and coarse prominent eosinophilic nucleoli |
3 |
FIGO recommendations:
(1) Tumors are graded on both architectural and nuclear criteria.
(2) The architectural grade usually takes precedence, For serous, clear cell and squamous cell carcinomas, nuclear grading takes precedence.
(3) If grade 3 nuclear atypia is seen with architectural grades 1 or 2, then the final grade should be reported as grades 2 or 3, respectively (increase architectural grade by 1).
My interpretation for this (excluding serous, clear cell and squamous cell carcinomas) is:
|
Architectural Grade |
Nuclear Grade |
Histologic Grade |
|
1 |
1 |
1 |
|
1 |
2 |
1 |
|
1 |
3 |
2 |
|
2 |
1 |
2 |
|
2 |
2 |
2 |
|
2 |
3 |
3 |
|
3 |
1 |
3 |
|
3 |
2 |
3 |
|
3 |
3 |
3 |
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
ICD-10: ,
