The immune reconstitution may be manifested as:
(1) onset or exacerbation of a quiescent or latent infection
(2) onset or exacerbation of an autoimmune disease
(3) onset or exacerbation of a disease with an immune component
Infections that have been associated with an IRS following delivery:
(1) tuberculosis or other mycobacterial disease
(2) deep fungal infection (cryptococcosis, coccidioidomycosis, etc)
(3) chronic viral hepatitis B or C
(4) herpesvirus
(5) anogenital warts
Autoimmune diseases that have shown IRS following delivery include:
(1) rheumatoid arthritis
(2) Graves's disease
(3) SLE
Diseases with an immune component the may show IRS following delivery:
(1) multiple sclerosis
(2) sarcoidosis
(3) hemolytic uremic syndrome
Some conditions (such as Guillain-Barre Syndrome) may worsen during pregnancy, only to improve following delivery.
The diagnosis requires exclusion of another causes, such as change in corticosteroid therapy or immunosuppression.
