A patient infected with Helicobacter pylori may develop an immune thrombocytopenic purpura (ITP). This may be related to chronic immune stimulation associated with longstanding gastritis.
Clinical features:
(1) gastritis caused by Helicobacter pylori
(2) unexplained thrombocytopenia with megakaryocytic hyperplasia in the bone marrow
(3) partial or marked rebound in platelet count after successful treatment of the H. pylori
(4) drop in platelet count with relapse of the infection
Differential diagnosis:
(1) ITP due to other cause
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