Sarcoidosis may rarely be associated with immune thrombocytopenic purpura (ITP).
Clinical and laboratory features:
(1) presence of sarcoidosis
(2) presence of severe thrombocytopenia
(3) presence of autoantibodies against platelets
(4) exclusion of other causes of ITP
(5) other causes of thromboytopenia in sarcoidosis (splenomegaly, bone marrow involvement, etc) cannot fully explain the thrombocytopenia
Bleeding may be difficult to control, and the ITP may be poorly responsive to therapy. Death can occur in some cases.
If the patient does not respond to corticosteroids, then rituximab or other therapy may be necessary.
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Specialty: Hematology Oncology
