Patient selection: systemic lupus erythematosus (SLE)
Measure of QOL: SF-36
Parameters:
(1) SELENA-SLEDAI (from 0 to 105; the range for SLEDAI-2K is the same; a score >= 4 is associated with some disease activity)
(2) physician global assessment (PGA, from 0 to 3)
(3) ESR in mm in first hour
Increases in these parameters are associated with decline in QOL.
Other factors impacting QOL:
(1) low serum complement
(2) high titer of anti-dsDNA
(3) active lupus nephritis
(4) musculoskeletal involvement
Factors impacting QOL:
(1) fatigue
(2) pain
(3) number and severity of organ dysfunction
(4) neuropsychiatric symptoms
(5) drug adverse effects
