Index of Wu et al for Predicting Significant Liver Fibrosis in a Patient Infected with Schistosoma japonica

 

Patient selection: infection with Schistosoma japonica

 

Measurement of fibrosis: ultrasonography

 

Outcome: distinguishing F2-F4 hepatic fibrosis from F0-F1

 

Parametes:

(1) INR

(2) serum hyaluronic acid in ng/mL (µg/L)

 

Both increase with progression of liver disease.

 

index =

= (INR) * (hyaluronic acid) /100

 

Interpretation:

• The cutoff was 1.2. An index >= 1.2 was associated with F2-F4 fibrosis.

 

Performance:

• The area under the ROC curve was 0.921.

 

Limitations:

• Other conditions such as alcohol abuse or chronic hepatitis can affect hepatic fibrosis.