Wyllie et al developed an index for predicting risk of 6-month mortality in a patient with thrombotic thrombocytopenic purpura (TTP) or hemolytic uremic syndrome (HUS). This can help identify a patient who may benefit from more aggressive management or a novel therapy. The authors are from the University of Western Ontario and University of Ottawa in Canada.
Parameters:
(1) age in years at presentation
(2) hemoglobin in g/dL at presentation
(3) temperature in °C at presentation
Parameters |
Finding |
Points |
age in years |
<= 40 years of age |
0 |
|
> 40 years of age |
2 |
hemoglobin |
>= 9.0 g/dL |
0 |
|
< 9.0 g/dL |
2 |
temperature |
<= 38.5°C |
0 |
|
> 38.5°C |
2 |
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 6
• The higher the score the greater the mortality.
Total Score |
6 Month Mortality |
0 or 2 |
12 - 14% |
4 |
31% |
6 |
62% |
Specialty: Hematology Oncology, Clinical Laboratory
ICD-10: ,