Paroxysmal nocturnal hemoglobinuria (PNH) may be associated with thrombosis. Hill et al listed when a patient with thrombosis should be screened for PNH. The authors are from St. Jame’s Hospital in Leeds.
Patient selection: thrombosis
Screening test to perform: flow cytometry
Indications to screen a patient with thrombosis:
(1) thrombosis otherwise unexplained
(2) young age
(3) thrombosis of an unusual site (dermal veins, cerebral veins, intra-abdominal veins)
(4) hemolysis
(5) any cytopenia
The presence of a normal serum LDH does not exclude PNH.
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