Fruit juices that can inhibit OATPA12:
(1) grapefruit
(2) apple
(3) orange
The juices contain a number of compounds that can inhibit the peptide:
(1) naringn, naringenin and other flavonoids
(2) bergamottin and other furanocoumarins
Drugs that may show impaired absorption if taken with the fruit juice:
(1) fexofenadine (grapefruit, orange)
(2) acebutolol (grapefruit)
(3) celiprolol (grapefruit, orange)
(4) talinolol (grapefruit)
(5) L-thyroxine (grapefruit)
(6) atenolol (orange)
(7) ciprofloxacin (orange)
Features of the interaction:
(1) erratic drug effect with difficulty adjusting drug dosages
(2) lower than expected blood levels of drug at peak absorption
(3) exclusion of other causes
(4) correction by avoiding fruit juices before or after taking the medicine
The interaction can be prevented by:
(1) not taking the affected medicine for 4 or more hours after drinking the fruit juice
(2) not drinking fruit juice for 2 hours after taking the medicine
