Concentration of the rhinal solution: 1 mL contains 0.1 mg desmopressin acetate which is equivalent to 400 IU.
Dosing:
(1) After removing the security seal from the bottle cap, the knurled seal is removed.
(2) The soft, plastic rhinal tube is placed over the exposed nozzle.
(3) The markings on the tube are at 0.05, 0.1, 0.15 and 0.2 mL. The correct volume of solution is passed into the tube.
(4) If the tube cannot be filled directly, then an insulin or tuberculin can be used to transfer the solution.
Self administration by older children or adults:
(1) One end of the tube is inserted about 0.75 inches (1.9 cm) into the nasal cavity.
(2) The breath is held and the head is tilted back.
(3) The opposite end is placed in the mouth and the solution is blown with a short, strong puff into the nasal cavity.
Administration to infants and small children:
(1) The intransal administration tube is inserted just enough to prevent the solution from running out.
(2) An adult blows the drug into the nasal cavity.
(3) An infant's head should be held firmly and securely during the administration.
Failures in administration:
(1) The solution running out the nares.
(2) The solution passes into the throat.
Drug storage:
(1) The knurled seal should be placed on the bottle nozzle once opened. This seal is a truncated cone. When shipped the wider end is nearer the bottle. After opening the seal should be reversed so that the wider end is away from the bottle. The seal prevents leakage, especially when the bottle is not kept upright or is compressed.
(2) The bottle should be refrigerated at 2 - 8°C (36 - 46°F). When traveling the bottle is stable for 3 weeks if kept at room temperature (between 20 - 25°C, or 68 - 77°F). The bottle should not be allowed to freeze or be exposed to higher temperatures. When flying in a plane the bottle should be packed in the carryon luggage.
