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Intravenous Immunoglobulin (IVIG) Resistance in Kawasaki Disease with Increased PLR and NLR

Description

The platelet-to-lymphocyte ratio (PLR) and the neutrophil-to-lymphocyte ratio (NLR) are markers of inflammation. Takeshita et al associated elevations of these ratios with intravenous immunoglobulin resistance in a patient with Kawasaki Disease. The authors are from National Defense Medical College and Japan Self-Defense Forces Central Hospital in Japan.


Patient selection: Kawasaki Disease

 

Parameters:

(1) platelet count

(2) absolute lymphocyte count

(3) absolute neutrophil count

 

platelet to lymphocyte ratio = PLR =

= (platelet count) / (absolute lymphocyte count)

 

neutrophil to lymphocyte ratio = NLR =

= (absolute neutrophil count) / (absolute lymphocyte count)

 

Interpretation:

• The presence of both NLR >= 3.83 and PLR >= 150 were associated with IVIG resistance.

 

Performance:

• The sensitivity was 72% and specificity 67%.


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