Tradewell et al reported a logistic regression model for predicting azoospermia in an infertile male. This can help to guide patient management. The authors are from the University of Miami, Universita Vita-Salute San Raffaele in Milan and University of Illinois at Chicago.
Patient selection: male with infertility
Parameters:
(1) age in years
(2) serum FSH in IU/L
(3) serum LH in IU/L
(4) serum testosterone in ng/dL
(5) mean testis volume in cubic cm
Parameter
Points
age in years
0.02 * (age)
serum FSH
0.13 * (FSH)
serum LH
0.03 * (LH)
serum testosterone
-0.002 * (testosterone)
mean testis volume
-0.08 * (volume)
value of X =
= SUM(points for all 5 parameters) - 1.9
probability of azoospermia =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curve ranged from 0.72 to 0.79 depending on study population.
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