Macro-TSH is a rare cause of a markedly elevated serum TSH in a patient who may otherwise be euthyroid.
Presentation:
(1) marked elevation of serum TSH
(2) normal serum T3 and T4 concentrations or minor deviations inconsistent with TSH
(3) absence of heterophile antibodies
Macro-TSH is a complex of TSH and IgG that is functionally inactive and which accumulates in the blood.
The diagnosis can be confirmed by gel filtration chromatography.
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Specialty: Clinical Laboratory, Endocrinology
