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Markers of Brousse et al for Disease Severity in Infants with Sickle Cell Anemia

Description

Brousse et al reported markers of disease severity in infants with sickle cell anemia. These can identify a patient who may benefit from more aggressive management. The authors are from multiple institutions in France, London and New York City.


Patient selection: infant with hemoglobin SS or hemoglobin S-beta thalassemia (beta-0)

 

Outcome: severe clinical event (acute splenic sequestration, vaso-occlusive event, transfusion requirement, abnormal cerebral Doppler velocity, death)

 

Markers of a severe clinical event at enrollment:

(1) hemoglobin <= 8 g/dL

(2) percent hemoglobin F <= 33.5%

 

Hemoglobin F percentage decreased over time with mean level of 21% at 24 months.


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