Maximum Steady State Concentration During an Intermittent Infusion

During an intermittent infusion the maximum concentration at steady state is at the end of the infusion.

At the end of the infusion the time since the dosing interval started = the infusion period. The equation in the previous section then becomes:

plasma drug concentration at steady state levels =

= (infusion rate) / (clearance) * (1 - EXP((-1) * k * (infusion period))) / (1 - EXP((-1) * k * (dosing interval)))

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