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Maximum Steady State Concentration for an Oral Drug

Description

For orally administered drugs, the maximum steady state concentration can be calculated if the kinetic parameters for the drug are known. This is the peak level.


 

Method 1

 

C(max-ss) =

= ((fraction orally absorbed) * (maintenance dose) / (volume of distribution) / (fraction of dose lost from body)) =

= ((fraction orally absorbed) * (maintenance dose) * (accumulation factor) / (volume of distribution))

 

fraction of dose lost from body =

= (1 - (EXP((-1) * (elimination rate constant) * (dosing interval))))

 

accumulation factor =

= (1 / (1 - EXP((-1) * (elimination rate constant) * (dosing interval))))

 

Method 2

 

C(max-ss) =

= ((C(min-ss)) + ((fraction orally absorbed) * (maintenance dose) / (volume of distribution)))

 


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Specialty

ICD-10