The M.D. Anderson Lower-Risk Prognostic Scoring System (LR-PSS, LRMDAS) can help to identify patients with a myelodysplastic syndrome with a better prognosis. This can help to further triage patients designated low risk by the IPSS.
Patient selection: myelodysplastic syndrome, low risk by the IPSS
Parameters:
(1) cytogenetics
(2) age in years
(3) hemoglobin in g/dL
(4) platelet count in 10^9/L
(5) percent blasts in the bone marrow
Parameter
Finding
Points
cytogenetics
normal
0
del(5q) alone
0
other (unfavorable)
1
age
< 60 years of age
0
>= 60 years of age
2
hemoglobin
>= 10 g/dL
0
< 10 g/dL
1
platelet count
> 200 * 10^9/L
0
50 to 200
1
< 50 * 10^9/L
2
percent blasts
< 4%
0
>= 4%
1
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 7
Total Score
Category
Median Overall Survival
0 to 2
1 (lower risk)
109 months
3 or 4
2
56 months
5 to 7
3
29 months
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