Poller et al reported a method for the rapid determination of the International Sensitivity Index (ISI) for a coagulometer. The authors are from the University of Manchester, Hospital of South West Denmark, University of Southern Denmark and Hart Biologicals, Ltd.
Line estimates for the plot of a series of data reflecting:
(1) x axis: LN(certified INR)
(2) y axis: LN(local PT in seconds)
ISI =
= 1 / (slope for the line)
mean normal prothrombin time = MNPT =
= EXP(intercept)
INR =
= ((measured PT) / (MNPT))^(ISI)
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