Features of microvesicular steatosis:
(1) very small fat droplets (made of triglycerides) that do not displace the hepatocyte nucleus, often in large numbers
(2) may only be evident on fat stain
(3) may be pure or mixed with macrosteatosis
Conditions associated with pure microvesicular steatosis:
(1) acute fatty liver of pregnancy
(2) Reye's syndrome
(3) drugs (Amiodarone, aspirin, chlortetracycline/tetracycline, didanosine, ketoprofen, tolmetin, valproic acid)
(4) heatstroke
(5) Jamaican vomiting sickness (ingestion of Ackee fruit)
(6) bacterial or chemical toxins
(7) sudden death
(8) toxic shock syndrome
(9) hepatitis D virus
(10) genetic metabolic disorders (carnitine transport defect, phospholipidoses, oxidative phosphorylation deficiency, medium-chain acyl coenzyme A dehydrogenase deficiency, long-chain acyl coenzyme A dehydrogenase deficiency, glutaric aciduria type II)
(11) alcoholic foamy deterioration
