Minipuberty of infancy is associated with a transient activation of the hypothalamic-pituitary-gonadal axis during the first few months of life.
Clinical features of minipuberty:
(1) An infant is less than 1 year of age.
(2) There is development of pubic and axillary hair.
(3) A female may experience breast enlargement and/or menstrual bleeding.
(4) A male may experience testicular and penile enlargement
Laboratory features:
(1) elevated serum testosterone in males and females
(2) elevated estradiol in females
The diagnosis requires exclusion of precocious puberty or other hormonal disorders.
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Specialty: Pedatrics, Obstetrics & Gynecology, Urology
