Hoster extended the Mangle Cell Lymphoma International Prognostic Index (MIPI) by the addition of the Ki-67 index. This improves risk stratification for patients with mantle cell lymphoma. The authors are from multiple hospitals in Europe.
Patient selection: mantle cell lymphoma
Parameters:
(1) MIPI
(2) Ki-67 index in percent
Parameter
Finding
Points
MIPI
low
0
intermediate
1
high
2
Ki-67 index
< 30%
0
>= 30%
1
MIPI-c =
= (points for MIPI) + (points for Ki-67 index)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the greater the risk.
MIPI-c
Risk Group
Median Overall Survival
0
low
9.4 years
1
low-intermediate
4.9 years
2
intermediate-high
3.2 years
3
high
1.8 years
survival from GLSG 1996 and 2000, Figure 2
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