Hernandez-Garcia et al reported a score to help differentiate multisystem inflammatory syndrome in a child (MIS-C) from sepsis. MIS-C may occur within a few weeks of SARS-CoV-2 infection. The authors are from multiple institutions in Spain.
Parameters:
(1) duration of fever in hours
(2) platelet count per microliter
(3) abdominal pain
(4) conjunctival erythema
(5) Vasoactive Inotropic Score (VIS)
Parameter
Finding
Points
duration of fever
<= 48 hours
0
> 48 hours
20
platelet count
>= 150,000 per µL
0
< 150,000 per µL (thrombocytopenia)
6
abdominal pain
no
0
yes
15
conjunctival erythema
no
0
yes
11
Vasoactive Inotropic Score
<= 10
0
> 10
7
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 59
• A score > 25 is associated with MIS-C.
Performance:
• At the cutoff the sensitivity is 0.89 and specificity 0.95.
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