Model of Alavi-Naini et al for the Diagnosis of Sputum Smear Negative Pulmonary Tuberculosis

Description

Alavi-Naini et al proposed a score for evaluating a patient for sputum smear negative pulmonary tuberculosis. This can help to identify a patient who should undergo additional testing for pulmonary tuberculosis. The authors are from Zahedan University of Medical Sciences in Iran and the Liverpool School of Tropical Medicine.

Patient selection: chronic cough with sputum smear negative for tuberculosis

Parameters (based on adjusted odds ratios):

(1) WBC count per microliter

(2) chest X-ray

(3) night sweats

(4) ESR in mm per hour

(5) family history of tuberculosis

Parameter	Finding	Points
WBC count	< 11,000 per µL	38.2
	>= 11,000 per µL	0
chest X-ray	typical for TB	24.4
	not typical for TB	0
night sweats	absent	0
	present	7.2
ESR	<= 45 mm per hr	0
	> 45 mm per hr	6.3
family history of TB	no	0
	yes	3.7

total score =

= SUM(points for all 5 parameters)

Interpretation:

• minimum score: 0

• maximum score: 79.8

• A score >= 45 is considered positive for tuberculosis.

Performance:

• The sensitivity was 94% and specificity 74%. at the proposed cut-off.

• The area under the ROC curve is 0.90.

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Model of Alavi-Naini et al for the Diagnosis of Sputum Smear Negative Pulmonary Tuberculosis

Description

Specialty