medical decision support 1 medical decision support 2
Subscribe Sign In

Model of Cella et al for Radiation-Induced Hypothyroidism

Description

Cella et al evaluated patients for the risk of hypothyroidism following radiation therapy to the neck. This can help guide radiation therapy planning. The authors are from the National Councel of Research in Naples and Federico II University in Naples.


Patient selection: radiation therapy to the neck

 

Analysis: normal tissue complication probability (NTCP)

 

Parameters:

(1) sex of the patient

(2) volume of the thyroid gland in mL (cc)

(3) volume of the thyroid gland exposed to >30 Gy in mL (cc)

 

Sex

Points

female

0

male

1

 

The total volume of the thyroid gland must be >= volume exposed to >30 Gy.

X =

= (-2.21 * (points for sex)) + (0.26 * (volume with > 30 Gy)) - (0.27 * (total volume)) + 1.94

 

probability of radiation-induced hypothyroidism =

= 1 / (1+EXP((-1) * X))

 

residual thyroid tissue not exposed to > 30 Gy =

= (total thyroid volume) - (volume of thyroid gland exposed to > 30 Gy)

 

If the residual thyroid gland has a volume >= 7 mL then there is a high probability that the patient will be euthyroid.


To read more or access our algorithms and calculators, please log in or register.

Specialty