Parejo et al reported a score for grading early allograft dysfunction in a liver transplant recipient. The authors are from Instituto de Investigacion Sanitaria La Fe and Universidad de Valaencia in Spain.
MEAF = Model for Early Allograft Function
Parameters:
(1) maximum serum ALT in the first 3 postoperative days, in U/L
(2) maximum INR iin the first 3 postoperative days
(3) serum total bilirubin on the third postoperative day in mg/dL
value of X =
= 1.9132 * (LN(ALT) - 6.1723)
points for ALT =
= 3.29/(1 + EXP((-1) * X))
value of Y =
= 6.8204 * (LN(INR) - 0.6658)
points for INR =
= 3.29/(1 + EXP((-1) * Y))
value of Z =
= 1.8005 * (LN(bilirubin) - 1.0607)
points for bilirubin =
= 3.4/(1 + EXP((-1) * Z))
total MEAF score =
= (points for serum ALT) + (points for INR) + (points for serum total bilirubin)
Interpretation:
• In the study population the MEAF shows a distribution that ranges from 0.06 to 9.73 with mean of 5.02 and standard deviation of 1.99.
• This was simplified to a range from 0 to 10.
• The graft loss rate was 31% for MEAF > 8.
• The mortality rate was 41% for MEAF > 8.
• There is a sharp rise in primary nonfunction for MEAF > 7.
