Frazee et al considered several models for predicting the vancomycin trough levels after 3 days of therapy. A model using the CKD-EPI based on serum creatinine and cystatin showed the best performance. The authors are from the Mayo Clinic.
Parameters:
(1) eGFR predicted by the CKD-EPI equation using serum creatinine and cystatin, in mg/min/1.73 square meter
(2) body surface area in square meters
(3) total vancomycin dose in grams for 3 days
(4) dosing interval
changing eGFR to mL per min =
= (eGFR) * (BSA) / 1.73
Parameter
Finding
Points
vancomycin dose
2.95 * (total dose)
dosing interval
every 8 hours
4.84
every 12 hours
1
every 24 hours
-7.70
eGFR
-0.163 * (changed eGFR)
predicted trough level in mg/L =
= SUM(points for all of the parameters) + 16.7
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