Hagstrom et al reported predictive markers for severe liver disease in the general population. This can help to identify a subset of patients who should be managed more aggressively. The authors are from Karolinska Institute and Stockholm University in Sweden.
Patient selection: adult >= 35 years
Outcome: severe liver disease (cirrhosis and its complications
Parameters:
(1) serum GGT
(2) impaired glucose tolerance (fasting glucose over 6 mmol/L OR non-fasting glucose over 7.8 mmol/L OR known diabetes)
(3) age in years
(4) FIB-4 as high, intermediate or low
|
FIB-4 |
Age < 65 years |
Age >= 65 years |
|
low |
<= 1.3 |
<= 2.0 |
|
intermediate |
1.31 to 2.67 |
2.01 to 2.67 |
|
high |
> 2.67 |
> 2.67 |
|
Serum GGT |
Impaired Glucose |
Age in Years |
FIB-4 |
Percent at 10 Years |
|
high |
impaired |
35 to 65 |
low |
2.62 |
|
|
|
|
intermediate |
10.66 |
|
|
|
|
high |
32.05 |
|
|
|
>= 66 |
low |
12.99 |
|
|
|
|
intermediate |
13.73 |
|
|
|
|
high |
29.10 |
|
|
not impaired |
35 to 65 |
low |
2.2 |
|
|
|
|
intermediate |
7.41 |
|
|
|
|
high |
25.41 |
|
|
|
>= 66 |
low |
3.55 |
|
|
|
|
intermediate |
0 |
|
|
|
|
high |
22.69 |
|
low |
impaired |
35 to 65 |
low |
0.64 |
|
|
|
|
intermediate |
1.03 |
|
|
|
|
high |
6 |
|
|
|
>= 66 |
low |
1.32 |
|
|
|
|
intermediate |
2.77 |
|
|
|
|
high |
12.45 |
|
|
not impaired |
35 to 65 |
low |
0.24 |
|
|
|
|
intermediate |
0.4 |
|
|
|
|
high |
5.53 |
|
|
|
>= 66 |
low |
0.61 |
|
|
|
|
intermediate |
0.67 |
|
|
|
|
high |
2.53 |
Specialty: Gastroenterology
