Kang et al reported a model for predicting one year risk of heart failure in a patient with acute leukemia following therapy with anthracyclines. The authors are from the University of Pennsylvania and Universidade Federal de Sao Paulo.
Patient selection: acute leukemia treated with anthracyclines.
Parameters:
(1) baseline global longitudinal strain in percent, -9 to -21 in the study
(2) pre-existing cardiovascular disease
(3) leukemia type (AML vs ALL)
(4) left ventricular ejection fraction (LVEF) in percent
(5) age in years
(6) anthracycline dose in mg per square meter
Parameter
Finding
Point
global longitudinal strain
<= -15%
0
> -15%
6
pre-existing cardiovascular disease
no
0
yes
4
leukemia type
AML
4
ALL
0
LVEF
>= 50%
0
< 50%
4
age in years
<= 60 years
0
> 60 years
1
anthracycline dose
< 250 mg per sq m
0
>= 250 mg per sq m
2
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 21
Total Score
Risk Category
1 Year Cumulative Incidence of Heart Failure
0 to 6
low
1%
7 to 13
moderate
13.6%
14 to 21
high
35%
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